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M94A2917.TXT
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1994-10-25
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Document 2917
DOCN M94A2917
TI Stereotactic brain biopsy of focal intracerebral lesions in AIDS
patients.
DT 9412
AU Cosin J; Miralles P; Moreno S; Parras M; Salazar F; Bouza E; Infectious
Diseases Unit, H.G. Maranon, Madrid, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):195 (abstract no. PB0207). Unique
Identifier : AIDSLINE ICA10/94369658
AB OBJECTIVE: To determine the prevalence of different etiologies of
intracerebral mass lesions unresponsive to empirical anti-toxoplasma
therapy and to evaluate the efficacy and security of stereotactic brain
biopsy. PATIENTS AND METHODS: During a period of 16 months, 23 cerebral
stereotactic biopsies were performed to 21 patients with intracerebral
masses. All patients had been treated against toxoplasma for at least 2
weeks with no clinical or radiologic response. Five patients showed
multiple lesions on CT scan and 18 patients showed a solitary lesion.
RESULTS: A definitive diagnosis could be established in all 21 patients
but a second biopsy was necessary in 2 patients. Diagnosis included
Non-Hodgkin's Lymphoma (12 cases), toxoplasmosis (6 cases), PML (2
cases), tuberculosis (1 case) and combined toxoplasmosis and
tuberculosis (1 case). The results of brain biopsy significantly
modified the management in all cases, and, in at least 11 patients,
supposed a benefit for them. There were no deaths nor significant
secondary effects after stereotactic biopsy. CONCLUSIONS: Stereotactic
brain biopsy is safe and useful for the management of intracerebral mass
lesions which do not respond to empirical antitoxoplasma treatment.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY
AIDS-Related Opportunistic Infections/DIAGNOSIS/*PATHOLOGY
Biopsy/*METHODS Brain/*PATHOLOGY Encephalitis/DIAGNOSIS/PATHOLOGY
Human Leukoencephalopathy, Progressive Multifocal/COMPLICATIONS/
DIAGNOSIS/*PATHOLOGY Lymphoma, AIDS-Related/DIAGNOSIS/*PATHOLOGY
Prevalence *Stereotaxic Techniques Toxoplasmosis,
Cerebral/DIAGNOSIS/*PATHOLOGY Tuberculoma/DIAGNOSIS/PATHOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).